Karyopharm Therapeutics Inc. (Nasdaq: KPTI), a commercial-stage pharmaceutical company pioneering novel cancer therapies, today announced the appointment of Lori Macomber as Executive Vice President, Chief Financial Officer and Treasurer, effective January 3, 2025. In this role, Ms. Macomber will be responsible for leading and directing the financial activities of the Company.
“Lori is an outstanding addition to the Karyopharm team,” said Richard Paulson, President and Chief Executive Officer of Karyopharm. “She brings extensive experience in strategic financial management and operations, which will be critical as we execute on our strategy to grow XPOVIO revenue and maintain our disciplined expense management as we progress our clinical pipeline.”
“I am thrilled to join Karyopharm at this important stage as we advance our pipeline of novel therapies and look forward to working with the leadership team and contributing to the Company’s success,” said Ms. Macomber. “I am impressed with both the team and the science and I am excited to be a part of bringing much needed therapies to patients.”
Ms. Macomber has over 20 years of diversified experience in leading growth and driving financial strategies for life science companies. She has a proven track record in financial management for companies ranging from start-up to Fortune 500 and has also successfully supported various collaboration partnerships, business development activities and licensing deals. Most recently, she served as Chief Financial Officer at Legend Biotech Corporation, a publicly traded, commercial-stage biopharmaceutical company. Previously, Ms. Macomber held leadership roles of increasing responsibility with Ametek PDS, Cello Health, Eli Lilly and Company, and Pfizer (formerly Pharmacia). Ms. Macomber holds a Bachelor of Science in Accounting from Pennsylvania State University and is a Certified Public Accountant.
In connection with Ms. Macomber’s appointment as Chief Financial Officer, effective as of January 31, 2025 (the Grant Date), the Company granted Ms. Macomber inducement awards consisting of (i) a non-statutory stock option to purchase 650,000 shares of Karyopharm’s common stock (the Inducement Option) and (ii) 160,000 restricted stock units (the Inducement RSU Award). These awards were granted pursuant to the Company’s 2022 Inducement Stock Incentive Plan, as amended, as inducements material to Ms. Macomber entering into employment with the Company in accordance with Nasdaq Listing Rule 5635(c)(4). The Inducement Option will have an exercise price per share of the closing price of Karyopharm’s common stock on the Nasdaq Global Select Market on the Grant Date and vests over four years, with 25% of the total number of shares underlying the stock option vesting on the first anniversary of the date Ms. Macomber commences employment and an additional 1/48th of the total number of shares underlying the option vesting monthly thereafter. The Inducement RSU Award will vest over three years, with 33 1/3% of the shares underlying the Inducement RSU Award vesting on each of the three consecutive anniversaries of the Grant Date. The vesting of each of the Inducement Option and the Inducement RSU Award is subject to Ms. Macomber’s continued service as an employee of, or other service provider to, Karyopharm through the applicable vesting dates. In addition, each of the Inducement Option and the Inducement RSU Award will immediately vest and/or become exercisable, as applicable, in full if, on or prior to the first anniversary of the consummation of a “change in control event,” Ms. Macomber’s employment is terminated by her for “good reason” or by Karyopharm without “cause” (as such terms are defined in the 2022 Inducement Stock Incentive Plan, as amended).
About Karyopharm Therapeutics
Karyopharm Therapeutics Inc. (Nasdaq: KPTI) is a commercial-stage pharmaceutical company whose dedication to pioneering novel cancer therapies is fueled by a belief in the extraordinary strength and courage of patients with cancer. Since its founding, Karyopharm has been an industry leader in oral compounds that address nuclear export dysregulation, a fundamental mechanism of oncogenesis. Karyopharm’s lead compound and first-in-class, oral exportin 1 (XPO1) inhibitor, XPOVIO® (selinexor), is approved in the U.S. and marketed by the Company in three oncology indications. It has also received regulatory approvals in various indications in a growing number of ex-U.S. territories and countries, including Europe and the United Kingdom (as NEXPOVIO®) and China. Karyopharm has a focused pipeline targeting indications in multiple high unmet need cancers, including in multiple myeloma, endometrial cancer, myelofibrosis, and diffuse large B-cell lymphoma (DLBCL). For more information about our people, science and pipeline, please visit www.karyopharm.com, and follow us on LinkedIn and on X.
